PH Clinical Groups

Group 1 PAH: idiopathic/heritable (BMPR2)/drug-toxin/connective tissue disease/HIV/portopulmonary/CHD/schistosomiasis/PVOD-PCH/persistent PH of the newborn

Group 2 Left heart disease: HF (HFpEF/HFmrEF/HFrEF/specific cardiomyopathies), valvular disease, and congenital/acquired cardiovascular disorders causing post-capillary PH

Group 3 Lung disease and/or hypoxia: obstructive/interstitial/mixed/other parenchymal lung disease/hypoventilation/high-altitude hypoxia/lung development disorders

Group 4 PA obstruction: chronic thromboembolic PH (CTEPH) and other PA obstructions

Group 5 Unclear/multifactorial: hematologic disorders, systemic diseases (sarcoidosis etc.), metabolic diseases, chronic renal failure, pulmonary tumor thrombotic microangiopathy, fibrosing mediastinitis, complex CHD